Valtrex, indications for use
- Treatment of herpes zoster;
- Treatment of diseases of the skin and mucous membranes caused by the Herpes simplex virus types 1 and 2 (including newly diagnosed and recurrent genital herpes);
- Prevention of recurrences of diseases of the skin and mucous membranes caused by the Herpes simplex virus types 1 and 2 (including genital herpes);
- Prevention of cytomegalovirus infection and diseases that develop after organ transplantation. Prevention with Valtrex reduces the reaction of rejection of the transplant, the development of infections caused by opportunistic microorganisms, and other viral infections (including herpes zoster).
Valtrex is contraindicated in patients with hypersensitivity to valacicpovir, acyclpovir and any auxiliary ingredient included in the formulation.
Use with caution in clinically expressed forms of HIV infection.
Clinical Trials Data
From the nervous system: often - a headache.
From the digestive tract: often - nausea.
On the part of the blood system and hemopoiesis: very rarely - leukopenia, thrombocytopenia. Basically, leukopenia was observed in patients with reduced immunity.
From the immune system: very rarely - anaphylaxis.
From the nervous system and psyche: rarely - dizziness, confusion, hallucinations, depression of consciousness; very rarely - agitation, tremor, ataxia, dysarthria, psychotic symptoms, convulsions, encephalopathy, coma. The above symptoms are mostly reversible and are usually observed in patients with impaired renal function or against a background of other predisposing conditions. In adult patients with a transplanted organ who receive high doses (8 g per day) of Valtrex for the prevention of CMV infection, neurologic reactions develop more often than with lower doses.
From the respiratory system and mediastinal organs: infrequently - shortness of breath.
From the digestive tract: rarely - discomfort in the abdomen, vomiting, diarrhea.
From the liver and bile ducts: very rarely - reversible violations of functional liver tests, which are sometimes regarded as manifestations of hepatitis.
From the skin and subcutaneous fat: rarely - rashes, including photosensitivity manifestations; rarely - itching; very rarely - hives, angioedema.
From the urinary system: rarely - a violation of kidney function; very rarely - acute renal failure, renal colic. Renal colic can be associated with impaired renal function.
Other: In patients with severe impairment of immunity, especially in adult patients with advanced HIV infection receiving high doses of valaciclovir (8 g daily) for a long period of time, renal failure, microangiopathic hemolytic anemia, and thrombocytopenia (sometimes in combination ). Similar complications were observed in patients with the same underlying and / or concomitant diseases, but not receiving valaciclovir.